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Week 16 NFL odds, picks, schedule, how to watch, streaming: Expert picks against the spread, best bets, more

Week 16 is here in the NFL, and CBSSports.com and SportsLine are breaking down every single game

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It’s Week 16 in the NFL, which means it’s Fantasy championship time in a vast majority of leagues. What happens this weekend will decide who walks away with a Fantasy title, unless the matchup involves Alvin Kamara; those are likely over after the Saints star gashed the Vikings for six rushing touchdowns on Christmas. But for anyone still competing or for anyone with teams chasing a playoff spot in the actual league, there are some major matchups on the way this weekend, including the Colts facing the reeling Steelers, the Rams and Seahawks battling for the NFC West crown and the Titans trying to beat the NFC-leading Packers in Green Bay.

Each week, we’ll collect all of the best picks and gambling content from CBSSports.com and SportsLine in one place, so you can get picks against the spread from our CBS Sports experts as well as additional feature content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff, survivor picks and more. 

Enjoy our run-through of Week 16, and good luck in your games! All NFL odds via William Hill Sportsbook.

What picks can you make with confidence in Week 16? And which Super Bowl contender goes down hard? Visit SportsLine to see which NFL teams are winning more than 50 percent of simulations, all from the model that is up over $7,800 on its top-rated picks.

Falcons at Chiefs

Time: Sunday, 1 p.m. ET (FOX), stream on fuboTV (Try for free) Latest Odds:Kansas City Chiefs -11

“Boy the Falcons can’t catch a break, can they? They blew a massive lead against Tom Brady (the jokes write themselves) and then roll right into a road matchup against Patrick Mahomes and the Chiefs. I don’t think Atlanta is going to put up much of a fight in this one, at least in terms of actually winning the game, but I do think the Chiefs have played too many close games to take them as a double digit favorite. They’re in cruise control for the No. 1 overall seed and I think Andy Reid will win without being too aggressive here.” — Will Brinson on why he has the Chiefs winning but the Falcons covering 

Brinson had the Saints as a best bet on Christmas and cashed that pretty easily, but you can see his best bets for every single Week 16 game in his Thursday column.

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